• Br. J. Haematol. · Feb 2015

    Multicenter Study

    Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.

    • Susanna Ranta, Ruta Tuckuviene, Anne Mäkipernaa, Birgitte K Albertsen, Tony Frisk, Ulf Tedgård, Ólafur G Jónsson, Kaie Pruunsild, Nadine Gretenkort Andersson, Maria Winther Gunnes, Sonata Saulyte Trakymiene, Thomas Frandsen, Mats Heyman, Ellen Ruud, and Jon Helgestad.
    • Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
    • Br. J. Haematol. 2015 Feb 1; 168 (4): 547-52.

    AbstractWe present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.© 2014 John Wiley & Sons Ltd.

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