• Semin Cardiothorac Vasc Anesth · Jun 2013

    Case Reports

    Treatment of acute silicoproteinosis by whole-lung lavage.

    • Marshall Stafford, Anthony Cappa, Michael Weyant, Abigail Lara, James Ellis, Nathaen S Weitzel, and Ferenc Puskas.
    • University of Colorado Denver, Aurora, CO 80045, USA. marshall.stafford@ucdenver.edu
    • Semin Cardiothorac Vasc Anesth. 2013 Jun 1; 17 (2): 152-9.

    AbstractAcute silicoproteinosis is a rare disease that occurs following a heavy inhalational exposure to silica dusts. Clinically, it resembles pulmonary alveolar proteinosis (PAP); silica exposure is thought to be a cause of secondary PAP. We describe a patient with biopsy-confirmed acute silicoproteinosis whose course was complicated by acute hypoxemic respiratory failure requiring mechanical ventilation. Without clinical improvement despite antibiotic and steroid treatment, the patient was scheduled for whole-lung lavage under general anesthesia. Anesthetic challenges included double-lumen tube placement and single-lung ventilation in a hypoxic patient, facilitating lung lavage, and protecting the contralateral lung from catastrophic spillage.

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