• J. Occup. Environ. Med. · May 2018

    MicroRNA Changes in Firefighters.

    • Kyoung Sook Jeong, Jin Zhou, Stephanie C Griffin, Elizabeth T Jacobs, Devi Dearmon-Moore, Jing Zhai, Sally R Littau, John Gulotta, Paul Moore, Wayne F Peate, Crystal M Richt, and Jefferey L Burgess.
    • Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Dr Jeong, Dr Griffin, Ms Dearmon-Moore, Ms Littau, Dr Burgess); Department of Occupational and Environmental Medicine, Graduate School of Medicine Dongguk University-Seoul, Dongguk University Ilsan Hospital, Goyang, Republic of Korea (Dr Jeong); Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Drs Zhou, Jacobs, Ms Zhai); Tucson Fire Department, Tucson, Arizona (Mr Gulotta, Mr Moore); WellAmerica, Tucson, Arizona (Dr Peate); University of Arizona Genetics Core, Arizona Research Laboratories, University of Arizona, Tucson, Arizona (Richt).
    • J. Occup. Environ. Med. 2018 May 1; 60 (5): 469-474.

    ObjectivesFirefighters have elevated cancer incidence and mortality rates. MicroRNAs play prominent roles in carcinogenesis, but have not been previously evaluated in firefighters.MethodsBlood from 52 incumbent and 45 new recruit nonsmoking firefighters was analyzed for microRNA expression, and the results adjusted for age, obesity, ethnicity, and multiple comparisons.ResultsNine microRNAs were identified with at least a 1.5-fold significant difference between groups. All six microRNAs with decreased expression in incumbent firefighters have been reported to have tumor suppressor activity or are associated with cancer survival, and two of the three microRNAs with increased expression in incumbent firefighters have activities consistent with cancer promotion, with the remaining microRNA associated with neurological disease.ConclusionIncumbent firefighters showed differential microRNA expression compared with new recruits, providing potential mechanisms for increased cancer risk in firefighters.

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