• Woo Jin Lee, Ik Jun Moon, Ho Jeong Shin, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, and Mi Woo Lee.
• Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
• Int. J. Dermatol. 2019 Jun 1; 58 (6): 688-696.

BackgroundThe prognostic value of CD30 expression in cutaneous extranodal natural killer/T-cell lymphoma is controversial.MethodsClinicopathological features, survival outcomes, and prognostic implications of CD30 were retrospectively analyzed in 55 patients with cutaneous extranodal natural killer/T-cell lymphoma. We classified patients into (i) primary cutaneous extranodal natural killer/T-cell lymphoma and (ii) cutaneous extranodal natural killer/T-cell lymphoma secondary to nasal disease depending on the primary tumor site.ResultsCD30+ cutaneous extranodal natural killer/T-cell lymphoma was more common in patients with cutaneous extranodal natural killer/T-cell lymphoma secondary to nasal disease than in those with primary cutaneous disease. CD30+ cases were more likely to present nodular lesions or cellulitis-like swelling than CD30- cases. Histologically, CD30+ cutaneous extranodal natural killer/T-cell lymphoma predominantly comprised large tumor cells compared with CD30- cases. However, the clinical morphology and tumor cell size were not associated with survival outcomes. CD30 expression was associated with better survival outcomes in patients with cutaneous extranodal natural killer/T-cell lymphoma secondary to nasal disease.ConclusionCD30+ cutaneous extranodal natural killer/T-cell lymphoma presented peculiar clinicopathological features and had more favorable disease course in patients with cutaneous dissemination from nasal disease.© 2018 The International Society of Dermatology.

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