• Marcia C Riyuzo, Liciana V de A Silveira, Célia S Macedo, and José R Fioretto.
• Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Pediatria, Botucatu, SP, Brazil. Electronic address: mriyuzo@fmb.unesp.br.
• J Pediatr (Rio J). 2017 Jan 1; 93 (1): 28-34.

ObjectiveTo evaluate the prognosis factors of children with sepsis and acute kidney injury.MethodsThis was a retrospective study of children with sepsis and acute kidney injury that were admitted to the pediatric intensive care unit (PICU) of a tertiary hospital. A multivariate analysis was performed to compare risk factors for mortality.ResultsSeventy-seven children (47 males) were retrospectively studied, median age of 4 months. Mean length of hospital stay was 7.33±0.16 days, 68.9% of patients received mechanical ventilation, 25.9% had oligo-anuria, and peritoneal dialysis was performed in 42.8%. The pRIFLE criteria were: injury (5.2%) and failure (94.8%), and the staging system criteria were: stage 1 (14.3%), stage 2 (29.9%), and stage 3 (55.8%). The mortality rate was 33.7%. In the multivariate analysis, the risk factors for mortality were PICU length of stay (OR=0.615, SE=0.1377, 95% CI=0.469-0.805, p=0.0004); invasive mechanical ventilation (OR=14.599, SE=1.1178, 95% CI=1.673-133.7564, p=0.0155); need for dialysis (OR=9.714, SE=0.8088, 95% CI=1.990-47.410, p=0.0049), and hypoalbuminemia (OR=10.484, SE=1.1147, 95% CI=1.179-93.200, p=0.035).ConclusionsThe risk factors for mortality in children with acute kidney injury were associated with sepsis severity.Copyright © 2016. Published by Elsevier Editora Ltda.

24 keywords...

hide…