• J. Infect. Dis. · Dec 2005

    Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early lyme disease.

    • Gary P Wormser, Richard Kaslow, Jianming Tang, Karen Wade, Dionysios Liveris, Ira Schwartz, and Mark Klempner.
    • Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA. gary_wormser@nymc.edu
    • J. Infect. Dis. 2005 Dec 1; 192 (11): 2020-6.

    BackgroundOn the basis of a polymerase chain reaction-restriction fragment-length polymorphism analysis of the 16S-23S ribosomal DNA intergenic spacer, clinical isolates of Borrelia burgdorferi can be classified into 3 genotypes designated as RST1, RST2, and RST3. RST1 strains are the most pathogenic, and RST3 strains are the least pathogenic.MethodsHuman leukocyte antigen (HLA) class II alleles were determined for a group of culture-positive patients with Lyme disease-associated erythema migrans and were evaluated for an association with the genotype of the infecting B. burgdorferi strain.ResultsThe DRB1*0101 allele carriage rate was higher in patients infected with RST3 strains (9/25 [36.0%]) than in patients infected with RST1 strains (2/28 [7.1%]) or RST2 strains (7/36 [19.4%]) (P=.010). The same relationship was found for carriage of the DRB1*0101-DQB1*0501 haplotype (P=.018), because of tight linkage disequilibrium. Similar associations could not be demonstrated for any of the other DRB1 and DQB1 alleles or haplotypes that were assessed.ConclusionThe DRB1*0101 allele and the DRB1*0101-DQB1*0501 haplotype may be relevant to the development of infection with strains from the least invasive genotypes of B. burgdorferi.

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