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- Yanfang Xia, Nizam Farah, Alexander Maxan, Juan Zhou, and Christian Lehmann.
- School of Basic Medical Sciences, Zhejiang University, Zhejiang, China.
- Med. Hypotheses. 2016 Apr 1; 89: 37-9.
AbstractSepsis represents the systemic immune response to an infection. Mortality of sepsis slightly decreased over the past years, but due to the growing incidence, the absolute number of deaths still increases and belongs to the three most frequent causes of death worldwide. To date, there is no specific treatment for sepsis available yet. Iron is essential to both human beings and microbes and of great significance in many physiological and biochemical processes. Since iron is involved in the bacterial proliferation and immune dysregulation, we hypothesize that restricting host iron levels by application of iron chelators attenuates bacterial growth and improves the detrimental dysregulation of the systemic immune response in sepsis. Copyright © 2016 Elsevier Ltd. All rights reserved.
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