• Nature medicine · Apr 2021

    Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.

    • Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R Fontes-Garfias, Hongjie Xia, Kena A Swanson, Mark Cutler, David Cooper, Vineet D Menachery, Scott C Weaver, Philip R Dormitzer, and Pei-Yong Shi.
    • Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
    • Nat. Med. 2021 Apr 1; 27 (4): 620-621.

    AbstractWe engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

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