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Int. J. Clin. Pract. · Sep 2021
COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak.
- Chiara Maria Trovato, Monica Montuori, Nicoletta Pietropaoli, and Salvatore Oliva.
- Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
- Int. J. Clin. Pract. 2021 Sep 1; 75 (9): e14452.
BackgroundA growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa: the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.MethodsBased on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.ConclusionsGenetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.© 2021 John Wiley & Sons Ltd.
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