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Bioorg. Med. Chem. Lett. · Nov 1998
Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP).
- J Li, X Luo, Q Wang, L M Zheng, I King, T W Doyle, and S H Chen.
- Vion Pharmaceutical, Inc., Four Science Park, New Haven, CT 06511, USA.
- Bioorg. Med. Chem. Lett. 1998 Nov 17; 8 (22): 3159-64.
AbstractWith the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.
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