• Malihe Hasanzadeh Mofrad, Fatemeh Homaei Shandiz, Fatemeh Vahid Roodsare, and Toktam Moghiman.
• Gynecology Oncology, Gynecologic Health Research Center and Cancer Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. HasanzadehMofradM@mums.ac.ir
• Asian Pac. J. Cancer Prev. 2010 Jan 1; 11 (1): 161-4.

PurposeThe anti- estrogen drug, tamoxifen, is one of the most important medications used in the treatment of both advanced and localized breast cancer. However, such tamoxifen use may have some risks related to the endometrium and ovaries. We followed a group of women with breast cancer on tamoxifen for the development of ovarian cysts.MethodsBased on a cross sectional study, 35 pre and post menopausal patients with breast cancer on tamoxifen were followed by pelvic exam and vaginal ultrasonography for 3 cycles of 3 month intervals; occurrence and outcome of ovarian cysts were evaluated.ResultsOf the 35 tamoxifen-treated patients enrolled in this study, 21 were postmenopausal and 14 were premenopausal. Their average age was 48.1+/-8.7 (range: 29-65 yrs) years. The mean duration of tamoxifen therapy was 30.5+/- 14 months (range: 12-60 months). Ovarian cysts were diagnosed in 12 (34.3%) patients, with surgery required in 6; pathological examination revealed malignancy in two cases.ConclusionDevelopment of ovarian cysts is a rather frequent event in women with breast cancer on tamoxifen. The majority of cysts are simple, which may resolve spontaneously or with discontinuation of tamoxifen, but malignancy needs to be ruled out.

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