-
Pediatric blood & cancer · Dec 2007
Case ReportsCorrection of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation.
- Suhag H Parikh, Paul Szabolcs, Vinod K Prasad, Sonali Lakshminarayanan, Paul L Martin, Timothy A Driscoll, and Joanne Kurtzberg.
- Division of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, North Carolina 27705, USA. suhag.parikh@duke.edu
- Pediatr Blood Cancer. 2007 Dec 1; 49 (7): 982-4.
AbstractAllogeneic hematopoietic stem cell transplantation (HSCT) is curative for chronic granulomatous disease (CGD), but many patients lack a suitably matched related donor. We report successful outcomes after mismatched, unrelated-donor umbilical cord blood transplantation (uUCBT) in two boys with X-linked CGD. Both patients experienced autologous recovery after first transplants, required second transplants to achieve durable donor engraftment, and are alive 27 and 15 months post-transplant. Both had invasive fungal disease and received granulocyte transfusions. In conclusion, uUCBT is effective in children with CGD, but immunosuppression in the conditioning regimen may need to be increased to decrease the risk of graft rejection.2007 Wiley-Liss, Inc
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..