• So Young Yang, Hyun Kang, Geun Joo Choi, Hwa Yong Shin, Chong Wha Baek, Yong Hun Jung, and Yoo Shin Choi.
• Department of Anaesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
• J. Int. Med. Res. 2014 Apr 1;42(2):307-19.

ObjectivesThis randomized, double-blind, placebo-controlled trial evaluated intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after laparoscopic cholecystectomy (LC).MethodsPatients who underwent LC were randomized to either group IV (intravenous lidocaine infusion), group IP (intraperitoneal lidocaine administration), or group C (control, IP and IV saline). Outcome measures were total postoperative pain severity (TPPS), total fentanyl consumption (TFC), frequency of administering patient-controlled analgesia (FPB), and a pain control satisfaction score (PCSS).ResultsSignificantly reduced TPPS, TFC and FPB scores were observed in groups IP (n = 22) and IV (n = 26) compared with controls (n = 24). PCSS was higher in groups IP and IV than in controls. At 2 h postoperation, TPPS was significantly lower in group IP than group IV; at 0-2 h postoperation, FPB was lower in group IP than group IV.ConclusionsThe IP administration of lidocaine and IV lidocaine infusion significantly reduced postoperative pain and opioid consumption in LC patients, compared with control infusions. For convenience, IV lidocaine could be used for pain reduction following LC; IP administration places additional burden on the surgeon.

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