• Semin Respir Crit Care Med · Feb 2009

    Review

    The role of gram-negative bacteria in healthcare-associated pneumonia.

    • Marcos I Restrepo and Antonio Anzueto.
    • Division of Pulmonary and Critical Care Medicine at the South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, Texas 78284, USA. restrepom@uthscsa.edu
    • Semin Respir Crit Care Med. 2009 Feb 1; 30 (1): 61-6.

    AbstractHealthcare-associated pneumonia (HCAP) is a unique entity that differs from community-acquired pneumonia in both bacteriology and outcomes and has similarities to hospital-acquired pneumonia and ventilator-associated pneumonia. HCAP patients are at higher risk of potential multidrug-resistant pathogens, including resistant gram-negative organisms, especially Pseudomonas aeruginosa and acinetobacter spp., but also extended-spectrum beta-lactamases (ESBLs). This manuscript reviews the epidemiology, etiology, and clinical outcomes of hospitalized HCAP patients due to gram-negative bacteria. We will focus our attention on the potential multidrug-resistant pathogens to suggest a new treatment approach for these patients.

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