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- Nam H Dang, Luis Fayad, Peter McLaughlin, Jorge E Romaguara, Fredrick Hagemeister, Andre Goy, Sattva Neelapu, Felipe Samaniego, Pamela L Walker, Michael Wang, Maria A Rodriguez, Ann T Tong, and Barbara Pro.
- Department of Hematologic Malignancies, Nevada Cancer Institute, Las Vegas, NV 89135, USA. ndang@nvcancer.org
- Br. J. Haematol. 2007 Aug 1; 138 (4): 502-5.
AbstractDenileukin diftitox plus rituximab was evaluated in relapsed/refractory B-cell non-Hodgkin lymphoma patients. Of the 38 evaluable patients, 30 (80%) were rituximab-refractory. The overall response rate (ORR) was 32%, with six complete responses (CR) and six partial responses (PR). The median time to progression for responders was 8 months (range: 2-36+); two patients with rituximab-refractory follicular lymphoma were in CR at 25 and 36+ months. The ORR was 55% (4 CRs, 2 PRs) in 11/14 patients with rituximab-refractory follicular lymphoma, and 100% in the three patients with rituximab-sensitive tumour. Most toxicities were low grade and transient, and myelotoxicity was uncommon.
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