• Clinics in chest medicine · Dec 2015

    Review

    Pulmonary Hypertension in Sarcoidosis.

    • Robert P Baughman, Peter J Engel, and Steven Nathan.
    • Department of Medicine, University of Cincinnati, 1001 Holmes Eden Avenue, Cincinnati, OH 45220, USA. Electronic address: bob.baughman@uc.edu.
    • Clin. Chest Med. 2015 Dec 1; 36 (4): 703-14.

    AbstractPulmonary hypertension is a complication of sarcoidosis leading to dyspnea and associated with increased morbidity and mortality. Sarcoidosis-associated pulmonary hypertension (SAPH) can be due to several factors, including vascular involvement by the granulomatous inflammation, compression of the pulmonary arteries by adenopathy, fibrotic changes within the lung, and left ventricular diastolic dysfunction. Several case series have suggested that some patients with SAPH benefit from specific therapy for pulmonary hypertension. A randomized, placebo-controlled trial found 16 weeks' bosentan therapy to be associated with significant improvement in pulmonary artery pressure. Future studies may better define who would respond to treatment of pulmonary hypertension. Copyright © 2015 Elsevier Inc. All rights reserved.

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