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Am. J. Physiol. Regul. Integr. Comp. Physiol. · Oct 2002
Gene expression analysis in burn wounds of rats.
- Marcus Spies, Mohan R K Dasu, Nenad Svrakic, Olivera Nesic, Robert E Barrow, J Regino Perez-Polo, and David N Herndon.
- Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston 77550, USA.
- Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002 Oct 1; 283 (4): R918-30.
AbstractThe events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expression of genes involved in cell survival and death, cell growth regulation, cell metabolism, inflammation, and immune response. The functional gene cluster detected and their time appearance matched the time sequence known to occur in burn wound healing.
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