• Clinics in chest medicine · Dec 2016

    Review

    Ventilator-induced Lung Injury.

    • Jeremy R Beitler, Atul Malhotra, and B Taylor Thompson.
    • Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 200 West Arbor Drive, #8409, San Diego, CA 92103, USA. Electronic address: jbeitler@ucsd.edu.
    • Clin. Chest Med. 2016 Dec 1; 37 (4): 633-646.

    AbstractPrevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.Copyright © 2016 Elsevier Inc. All rights reserved.

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