• Curr Neurol Neurosci Rep · Jan 2008

    Review

    Chemotherapy-induced peripheral neuropathy.

    • Bushra Malik and Mark Stillman.
    • Section of Headache and Pain, Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. stillmm@ccf.org
    • Curr Neurol Neurosci Rep. 2008 Jan 1; 8 (1): 56-65.

    AbstractRecent advances in the development and administration of chemotherapy for malignant diseases have led to prolonged survival of patients and the promise of a return to normal lives. The cost of progress comes with a price, however, and the nervous system is frequently the target of therapy-induced toxicity. Unlike more immediate toxicities that affect the gastrointestinal tract and bone marrow, chemotherapy-induced neurotoxicity is frequently delayed in onset and may progress over time. In the peripheral nervous system, the major brunt of the toxic attack is directed against the peripheral nerve, targeting the neuronal cell body, the axonal transport system, the myelin sheath, and glial support structures, resulting in chemotherapy-induced peripheral neuropathy.

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