• Nature medicine · Nov 1999

    Inflammatory thoughts about glioma gene therapy.

    • T Kielian and W F Hickey.
    • Nat. Med. 1999 Nov 1; 5 (11): 1237-8.

    AbstractGene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256-1263).

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