• Hongying Lou, Dong Huang, Suhua Fang, Xiaofeng Zhao, Qiongxiao Huang, and Minzhen Wang.
• Affiliated Sir Run Run Shaw Hospital, School of Medcine, Zhejiang University, Hangzhou 310016, China.
• Zhongguo Zhong Yao Za Zhi. 2009 Nov 1; 34 (22): 2950-2.

ObjectiveTo observe the clinical effects and the serous estradiol change of patients with menopause syndrome using Xianling Gubao capsules for treatment.Method110 patients with manopause syndrome who were diagnosized by clinic index were recruited for the study. They were divided into two groups randomly. The treatment group were dealed with Xianling Gubao capsules and the control group with placebo of starch capsules for 8 weeks. The menopausal Kupperman index was used to assess change in menopausal symptoms before and after treatment. At the same time, serous estradiol and the thickness of uterine endometrium was evaluated.ResultThe Kupperman index were improved apparently in treatment group after treatment (P < 0.01). The serous estradiol level of treatment group was increased apparently after treatment (P < 0.05). However, There were no statistical deference in the thickness of uterine endometrium in the treatment and the control group before and after treatment.ConclusionThe treatment using Xianling Gubao capsules for patients with menopause syndrome could improve the clinic symptoms, increase the serous estradiol level, but do not increase the risk of endometrial hyperplasia.

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