• Alfonso J Rodriguez-Morales, Jaime A Cardona-Ospina, Valeria Ramirez-Jaramillo, Javier A Gaviria, Gloria María González-Moreno, Juan D Castrillón-Spitia, Alejandra López-Villegas, Estefania Morales-Jiménez, Valentina Ramírez-Zapata, German Eduardo Rueda-Merchán, Adriana M Trujillo, Fredy A Tabares-Villa, Valentina Henao-SanMartin, David R Murillo-Garcia, Johana Andrea Herrera-Soto, Marta Liliana Buitrago-Cañas, Matthew H Collins, Juan Carlos Sepúlveda-Arias, José J Londoño, Héctor D Bedoya-Rendón, Javier de Jesús Cárdenas-Pérez, Sandra X Olaya, and Guillermo J Lagos-Grisales.
• Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia; Infection and Immunity Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Medical School, Faculty of Health Sciences, UniFranz, Cochabamba, Bolivia. Electronic address: arodriguezm@utp.edu.co.
• Travel Med Infect Dis. 2018 Sep 1; 25: 20-25.

BackgroundZika virus (ZIKV) infection has emerged as a significant threat for pregnant women and newborns in populations living in or visiting Latin America. We previously reported a preliminary analysis in Sucre, Colombia, as the first group of pregnant women with RT-PCR-confirmed ZIKV (ZIKa enEmbarazadas yReciénNacidos enCOLombia, ZIKERNCOL).MethodsIn this second report, findings of the first 86 pregnant women from La Virginia and Dosquebradas (municipalities), Risaralda, Colombia, with RT-PCR-confirmed ZIKV infection are reported. Clinical, demographical and obstetrical findings are described.ResultsAll women reported ZIKV symptoms during pregnancy: 79.1% rash, 55.8% fever, among others. In addition to ZIKV, RT-PCR was positive for dengue in 18.6%; 45.3% Dengue IgM+; 5.8% RT-PCR positive for chikungunya; 3.6% Chikungunya IgM+. STORCH screening in mother: 11.6% IgG + anti-Toxoplasma gondii, 6% IgG + anti-rubella, 4.7% IgG + CMV. The rest of STORCH tests were negative. Microcephaly was observed in 2.4% of the newborns. No calcifications or other CNS alterations were detected. One newborn had cleft palate and one had bilateral renal ectopy.ConclusionsThe rate of microcephaly in our cohort was consistent with other studies. Pregnant women in endemic areas should be followed and tested according to standard protocols, and asymptomatic ZIKV infection should be considered. Long-term follow-up of children is required in the congenital Zika syndrome (CZS) assessment.Copyright © 2018 Elsevier Ltd. All rights reserved.

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