• Clin. Microbiol. Infect. · Jan 2008

    Review

    Genetic support of extended-spectrum beta-lactamases.

    • L Poirel, T Naas, and P Nordmann.
    • Service de Bactériologie-Virologie, Hôpital de Bicêtre, South-Paris Medical School, University Paris XI, Le Kremlin-Bicêtre, France. laurent.poirel@bct.aphp.fr
    • Clin. Microbiol. Infect. 2008 Jan 1; 14 Suppl 1: 75-81.

    AbstractGenes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are mostly either TEM or SHV derivatives, CTX-M-like enzymes--now emerging worldwide--or, less frequently, VEB, GES, and PER ESBLs. The mechanisms responsible for their acquisition are very diverse, and mostly are related to insertion sequences (ISs), transposons, class 1 integrons, and also sul1-type integrons containing the ISCR1 element. This diversity of genetic vehicles at the origin of these mobilisation/acquisition processes enhances the spread of ESBLs.

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