• J. Infect. Dis. · Jun 2005

    Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43.

    • Xiao-Yan Che, Li-Wen Qiu, Zhi-Yong Liao, Ya-di Wang, Kun Wen, Yu-Xian Pan, Wei Hao, Ya-Bo Mei, Vincent C C Cheng, and Kwok-Yung Yuen.
    • Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, People's Republic of China. linche@pub.guangzhou.gd.cn
    • J. Infect. Dis. 2005 Jun 15; 191 (12): 2033-7.

    AbstractCross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.

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