• J Vet Emerg Crit Care (San Antonio) · Sep 2018

    Effects of esmolol on systemic hemodynamics and heart rate variability measured using the Analgesia/Nociception Index in resuscitated piglets with Pseudomonas aeruginosa septic shock.

    • Emmanuel Boselli, Matthias Jacquet-Lagrèze, Jean-Yves Ayoub, Lionel Bouvet, Olivier Dauwalder, Christelle Mansour, Thomas Margez, Christian Paquet, Damien Restagno, Bernard Allaouchiche, Jeanne-Marie Bonnet-Garin, and Stéphane Junot.
    • VetAgro Sup UPSP 2016.A101- Campus vétérinaire de Lyon, Agressions Pulmonaires et Circulatoires dans le Sepsis (APCSe), Marcy-l'Étoile, France, Université Lyon I Claude Bernard, Université de Lyon, Lyon, France.
    • J Vet Emerg Crit Care (San Antonio). 2018 Sep 1; 28 (5): 447-456.

    ObjectiveTo determine the effects of esmolol on hemodynamics and heart rate variability (HRV) in the early stage of sepsis.DesignProspective, randomized, controlled, parallel trial.SettingsVeterinary research laboratory.AnimalsTen anesthetized piglets.InterventionsSeptic shock was induced by infusing a suspension of live Pseudomonas aeruginosa IV in 10 anesthetized piglets. The piglets were resuscitated according to a standardized protocol using Ringer's lactate solution, norepinephrine, and milrinone. Once stabilized, the piglets were randomized to receive IV esmolol, titrated to a heart rate <90/min, or control, receiving saline. A pulmonary artery catheter and an arterial catheter were inserted for hemodynamic measurements. The Analgesia/Nociception Index (ANI) and the normalized HRV frequency domain parameters - high-frequency (HF), low frequency (LF), LF/HF ratio - were recorded using a proprietary monitor.Measurements And Main ResultsA significant decrease in cardiac output and heart rate, and a significant increase in systemic vascular resistance were observed over time in the esmolol group in comparison to the control group. No other differences were observed in hemodynamic parameters. No significant differences were observed in ANI variations or HRV parameters over time between groups.ConclusionsThe administration of esmolol produced significant changes in hemodynamics with no change in ANI values or HRV parameters. Further study is needed to understand the effect of esmolol during sepsis.© Veterinary Emergency and Critical Care Society 2018.

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