• Zhongguo Zhong Yao Za Zhi · Aug 2012

    Historical Article

    [Current situation of toxicity classification of Chinese materia medica and its research thoughts].

    • Wenyan Sun, Xiujuan Hou, Bin Wang, Yuelan Zhu, Shuofeng Zhang, Hongsheng Chang, and Jianning Sun.
    • Department of Pharmacology of Chinese Materia Medica, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. wenyansun@yahoo.com.cn
    • Zhongguo Zhong Yao Za Zhi. 2012 Aug 1; 37 (15): 2199-201.

    AbstractToxicity of Chinese materia medica (CMM) is an important part of Chinese herbal nature theory. In clinical application, the dosage, time limitation and compatibility of CMM is mainly determined by toxicity. At present, there is no uniform toxicity classification standard for the evaluation of Chinese herbal toxicity. Therefore, it is significant to research toxicity classification of CMM. The current situation of toxicity classification of CMM is reviewed in this paper, and proposed research thoughts are as follows: the measurement of toxicity parameters, the confirmation of poisoning target organs, the investigation on toxic mechanism by serum pharmacology and toxicokinetics, the comprehensive evaluation on toxicity based on quantitative theory.

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