• Dmytro Unukovych, Kerstin Sandelin, Annelie Liljegren, Brita Arver, Marie Wickman, Hemming Johansson, and Yvonne Brandberg.
• Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden. Dmytro.Unukovych@ki.se
• Eur. J. Cancer. 2012 Nov 1; 48 (17): 3150-6.

IntroductionContralateral prophylactic mastectomy (CPM) is the most effective option to prevent the occurrence of a second breast cancer in hereditary breast cancer patients. This study aimed to prospectively evaluate health-related quality of life (HRQoL), anxiety and depression, sexuality and body image in breast cancer patients with a family history undergoing CPM with immediate breast reconstruction.Patients And MethodsIn total, 60 of 69 eligible patients agreed to participate in the study. Four validated questionnaires were used: the SF-36, the Hospital Anxiety and Depression Scale (HAD), the Body Image Scale (BIS), and the Sexual Activity Questionnaire (SAQ). Forty-five patients (75%) responded before CPM, 49 (82%) at 6 months, and 45 (75%) at 2 years after CPM.ResultsOverall, the patients showed a satisfactory HRQoL 2 years after CPM, similar to women in the general population. There were no differences in HRQoL, anxiety, depression or sexuality before and after CPM. However, more than half of the women reported at least one body image problem 2 years postoperatively.ConclusionNo adverse effects on HRQoL, anxiety, depression or sexuality were observed. However, some aspects of body image were negatively affected after CPM. These findings could be used in preoperative counselling of breast cancer patients opting for CPM.Copyright © 2012 Elsevier Ltd. All rights reserved.

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