• Zhongguo Zhong Yao Za Zhi · Jul 2010

    [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].

    • Jing Wang, Xinzhuang Zhang, Xiaoyan Wu, Xiaoli Zhao, Liuqing Di, Qing Guo, and Shouchuan Wang.
    • Nanjing University of Chinese Medicine, Nanjing 210029, China.
    • Zhongguo Zhong Yao Za Zhi. 2010 Jul 1; 35 (13): 1702-5.

    ObjectiveTo develop a HPLC method for the simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao' erjinning oral liquid.MethodThe chromatographic separation was achieved on a Lichrospher C18 (4.6 mm x 250 mm, 5 microm) column with a mobile phase which was composed of acetonitrile(A) and 0.4% phosphoric acid(B) for gradient elution (10:90-18:82-27:73). The flow rate was (0.8-1.1-0.8) mL x min(-1), the column temperature was 30 degrees C and the detection wavelength was set at 300 nm.ResultThe results showed that 6 effective components were separated well and showed good linearity. The average recoveries were between 95%-105%.ConclusionThe method is proved to be rapid, accurate, credible and repeatable. It can be used for the quality control of Xiao'erjinning oral liquid.

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