• Scand. J. Gastroenterol. Suppl. · Jan 1988

    Comparative Study

    An N of 1 service: applying the scientific method in clinical practice.

    • J L Keller, G H Guyatt, R S Roberts, J D Adachi, and D Rosenbloom.
    • Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario.
    • Scand. J. Gastroenterol. Suppl. 1988 Jan 1; 147: 22-9.

    AbstractThe N of 1 service at our institution acts as a full referral service for clinicians who want a definitive answer to a difficult management question, and an instructional environment for clinicians who have more time and want to learn to run their own N of 1 RCT. The trial design is a double blind, randomized pair, multiple crossover. A number of methodologic issues are discussed, such as appropriateness of the patients problem to N of 1 trials, feasibility, types of measurement, such as clinical objective measurement and quality of life measurement, as well as timing of these measurements. The analysis issues include developing a reporting method which is statistically powerful and understandable to clinicians with little research background. Some of these issues have been well investigated and some have not.

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