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Zhongguo Zhong Yao Za Zhi · Dec 2010
[Correlation of powder properties and formability of traditional Chinese medicine pellets].
- Yang Huang, Xiaobin Jia, Jing Zhu, Bin Chen, Hongxia Chen, and Qi Liu.
- Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. shoujiao.student@sina.com
- Zhongguo Zhong Yao Za Zhi. 2010 Dec 1; 35 (23): 3136-9.
ObjectiveTo investigate the correlation of powder properties and formability of traditional Chinese medicine pellets prepared by extrusion/spheronization.MethodThe present effort was designed to evaluate the effects of the characters of powder on pellets formation by extrusion-spheronization, taking Danggui Buxue decoction extracts as a model drug and microcrystalline cellulose (MCC) as an ideal balling material for extrusion-spheronization.ResultThe diameter of powder had correlation with the plane critical angle of pellets in a certain scope and the sticky coefficient of wet mass affected roundness of pellets.ConclusionProperties of powder have influence on formability of traditional Chinese medicine pellets.
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