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- H Petersen, I Løge, T Johannessen, U Fjøsne, P M Kleveland, P Kristensen, P Sandbakken, P E Hafstad, and T Halvorsen.
- Scand. J. Gastroenterol. Suppl. 1987 Jan 1; 128: 108-13.
AbstractNon-ulcer dyspepsia (NUD) is a poorly defined heterogenous condition less well suited for the conventional randomized and placebo controlled parallel type trials. We have designed a multi cross-over model (MCO-model) with the facility of providing information about drug responses in individual patients. A pilot study suggested that the model may identify individual cimetidine responders among patients with dyspepsia. Preliminary findings from an ongoing study in patients with NUD supports the existence of a subgroup of cimetidine responders characterized by gastroesophageal reflux symptoms and possibly an increased basal acid secretion.
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