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J Clin Psychopharmacol · Apr 1989
Clinical Trial Controlled Clinical TrialAdverse effects of fenfluramine in treatment refractory schizophrenia.
- B D Marshall, S M Glynn, K K Midha, J W Hubbard, L L Bowen, L Banzett, J Mintz, and R P Liberman.
- Department of Psychology, University of California, Los Angeles.
- J Clin Psychopharmacol. 1989 Apr 1; 9 (2): 110-5.
AbstractFenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.
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