• Ronan Thenault, Anis Gasmi, Zine-Edine Khene, Karim Bensalah, and Romain Mathieu.
• Department of Urology, Service d'urologie, Rennes University Hospital, Hôpital Pontchaillou.
• Curr Opin Urol. 2021 Jul 1; 31 (4): 424-429.

Purpose Of ReviewRadiogenomics, fusion between radiomics and genomics, represents a new field of research to improve cancer comprehension and evaluation. In this review, we give an overview of radiogenomics and its most recent and relevant applications in prostate cancer management.Recent FindingsLiterature about radiogenomics in prostate cancer emerged last 5 years but remains scarce. Radiogenomics in prostate cancer mainly rely on MRI-based features. Several imaging biomarkers, mostly based on the identification of radiomic features from deep learning studies, have been studied for the prediction of genomic profiles, such as PTEN Decipher Oncotype DX or Prolaris expression. However, despite promising results, several limitations still preclude any integration of radiogenomics in daily practice.SummaryIn the future, the emergence of artificial intelligence in urology, with an increasing use of radiomics and genomics data, may enable radiogenomics to assume a growing role in the evaluation of prostate cancer, with a noninvasive and personal approach in the field of personalized medicine. Further efforts are necessary for integration of this promising approach in prostate cancer decision-making.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

9 keywords...

hide…