• Surg Gynecol Obstet · Jan 1980

    Comparative Study

    Gastrin and gastric acid secretion in hepaticojejunostomy Roux-en-Y.

    • M L Nielsen, S L Jensen, J Malmstrøm, and O V Nielsen.
    • Surg Gynecol Obstet. 1980 Jan 1; 150 (1): 61-4.

    AbstractReports on increased duodenal ulceration after bile diversion prompted the present investigation of gastric acid secretion and gastrin in 16 patients with a Roux-en-Y hepaticojejunostomy and 11 patients with a choledochoduodenostomy. Basal and pentagastrin stimulated acid output, gastrin in serum and gastrin in the antral mucosa were all significantly elevated in patients with a Roux-en-Y compared with those patients having a choledochoduodenostomy. In patients with a Roux-en-Y, bile bypassed the duodenum and the most proximal part of the jejunum; it is hypothesized that the bypass of bile may induce gastric acid hypersecretion secondary to an altered biosynthesis and release of gastrin.

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