• Bioorg. Med. Chem. Lett. · Dec 2010

    Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.

    • Jeremiah P Malerich, Jennifer S Lam, Barry Hart, Richard M Fine, Boris Klebansky, Mary J Tanga, and Annalisa D'Andrea.
    • SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
    • Bioorg. Med. Chem. Lett. 2010 Dec 15; 20 (24): 7454-7.

    AbstractTyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.Copyright © 2010 Elsevier Ltd. All rights reserved.

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