• Ann Dermatol Vener · Apr 2013

    Case Reports

    [Limbic encephalitis: a new paraneoplastic auto-immune manifestation associated with metastatic melanoma?].

    • C Becquart, G Ryckewaert, E Desmedt, L Defebvre, E Le Rhun, and L Mortier.
    • Service de dermatologie, hôpital Claude-Huriez, rue Michel-Polonovski, 59037 Lille cedex, France. coralie.becquart@univ-lille2.fr
    • Ann Dermatol Vener. 2013 Apr 1; 140 (4): 278-81.

    BackgroundSeveral studies indicate an association between immune-related manifestations and prolonged survival in metastatic melanoma. Limbic encephalitis driven by immune-mediated disorders may also be observed during the course of certain cancers.Patients And MethodsIn November 2009, a 60-year-old woman followed up for metastatic melanoma since July 2005 developed rapidly progressive cognitive disorder. Clinical, biological, MRI and electroencephalogram abnormalities resulted in diagnosis of probably paraneoplastic limbic encephalitis in a context of immune-related manifestations although chemotoxicity could not be ruled out. Auto-immunity with hypothyroidism and thrombocytopenia were seen concomitantly.DiscussionTo the best of our knowledge, this is the first reported case of probably paraneoplastic limbic encephalitis associated with melanoma, a new example of an immune-related condition associated with prolonged survival in metastatic melanoma.Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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