• Scand. J. Gastroenterol. Suppl. · Jan 1981

    Inhibition of experimental stress ulcer formation in rats.

    • H F Fehr, M Aebi, J Finger, and G H Clémençon.
    • Scand. J. Gastroenterol. Suppl. 1981 Jan 1; 67: 187-9.

    AbstractWe present an operation model in rats, which according to our opinion prevents duodenogastric reflux effectively. The duodenum is divided distally from the pylorus and a pyloro-jejunostomy performed combined with a Roux-en-Y anastomosis. Rats operated this way and submitted to restraint stress developed significantly less stress lesions than operated control under same conditions. However, operated rats submitted to the operation and offered a 5 mMol/l drinking solution of crude taurocholic acid during 20 days before submitted to stress had significantly more stress lesions than operated animals with tap water before restraint stress.

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