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Zh Nevropatol Psikhiatr Im S S Korsakova · Jan 1989
Comparative Study[Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents].
- A B Katasonov, B S Beliaev, O S Brusov, G P Zlobina, and M I Faktor.
- Zh Nevropatol Psikhiatr Im S S Korsakova. 1989 Jan 1; 89 (12): 75-8.
AbstractEffective 5-HT concentration eliciting the half-maximal rate of platelet deformation (aggregation) in drug-free bipolar or unipolar depressed women was significantly (p less than 0.001) lower as compared with matched controls (0.13 +/- 0.04 microM and 0.532 +/- 0.1 microM, respectively). After 1-3 months of antidepressant treatment this value increased to 0.47 +/- 0.16 microM and was no longer different from control. Possible mechanisms controlling the activity of serotonin2 platelet receptors are discussed.
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