• R L Chatburn, M D Lough, and J D Klinger.
• Resp Care. 1984 Sep 1; 29 (9): 893-9.

AbstractIt is generally recognized that nebulizers can be a source of nosocomial infection. 'Cold mist' room humidifiers are a particular problem because they are difficult to sterilize. We evaluated a new device, the Sonic Mist ultrasonic room humidifier, to determine how quickly it became contaminated during continuous use by a population of cystic fibrosis patients. In addition, the study was designed to test the effectiveness of placing a bacterial filter on the air inlet of the humidifier. We found that the entire humidifier could withstand repeated gas sterilization. Data obtained from 18 humidifiers involving cystic fibrosis patients indicate that the earliest humidifier contamination occurred after 5 days of continuous use. Although all patients had large numbers of gram-negative bacilli as predominant sputum flora, only 7 episodes of contamination were found during 34 humidifier-use periods. Three units equipped with filters became contaminated (5-7 days) and four unfiltered units became contaminated (6-11 days), indicating that the use of an inlet filter made no apparent difference. The organisms recovered from contaminated units were not found as sputum flora and would not generally be considered of clinical significance in cystic fibrosis sputum cultures. Probable sources of the organisms were room dust and hand contamination. A further test of the inlet filter was performed by exposing filtered and unfiltered units to mist from an intentionally contaminated humidifier. Again, the contamination rate was low and the filter apparently made no difference. These results indicate that the Sonic Mist humidifier may be appropriate for hospital use if adequate sterilization and contamination-monitoring practices are followed.

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