• J Clin Psychopharmacol · Dec 1987

    Review

    Modifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression.

    • P Blier, C de Montigny, and Y Chaput.
    • Neuroscience Research Center, Montreal, Quebec, Canada.
    • J Clin Psychopharmacol. 1987 Dec 1; 7 (6 Suppl): 24S-35S.

    AbstractResults of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. Tricyclic antidepressants, electroconvulsive shock treatment, mianserin, adinazolam, and possibly sleep deprivation may exert their therapeutic effect through sensitization of postsynaptic neurons to 5-HT. Serotonin reuptake blockers may relieve depression through an increased efficacy of the presynaptic element resulting from a desensitization of somatodendritic and terminal 5-HT autoreceptors. Similarly, monoamine oxidase inhibitors may act by increasing the efficacy of 5-HT neurons. Intensification of 5-HT function appears to be a common denominator to antidepressant treatments; however, evidence suggests that this modification may only be a link in a chain of events leading to an antidepressant response.

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