• J. Allergy Clin. Immunol. · Jul 2000

    Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation.

    • H Nakamura, K Komatsu, M Ayaki, S Kawamoto, M Murakami, N Uoshima, T Yagi, T Hasegawa, M Yasumi, T Karasuno, H Teshima, A Hiraoka, and T Masaoka.
    • Department of Tumor Biochemistry, the Fifth Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
    • J. Allergy Clin. Immunol. 2000 Jul 1; 106 (1 Pt 2): S45-50.

    BackgroundAcute graft-versus-host disease still represents the major factor that limits successful allogeneic bone marrow transplantation. Cytokines released by type 1 T-helper cells are thought to play a pivotal role in acute graft-versus-host disease.ObjectiveThis study was performed to investigate whether the serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma were associated with the manifestation of acute graft-versus-host disease.MethodsSerum cytokine levels were measured by sandwich ELISA in 18 patients who underwent allogeneic bone marrow transplantation.ResultsSerum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma were increased in patients in whom acute graft-versus-host disease developed. However, only serum soluble IL-2 receptor levels were significantly related to disease severity. Serum levels of IL-12 and IL-18, both of which are mainly produced by activated macrophages, were increased in different phases of acute graft-versus-host disease, especially grade I. Serum levels of soluble IL-2 receptor and IFN-gamma were significantly elevated in patients with fever.ConclusionSerum levels of soluble IL-2 receptor were more closely related to the severity of acute graft-versus-host disease than those of IL-12, IL-18, and IFN-gamma.

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