• J. Korean Med. Sci. · Sep 2018

    Therapeutic Effects of Leuprorelin (Leuprolide Acetate) in Sexual Offenders with Paraphilia.

    • Jong Hyuk Choi, Jae Woo Lee, Jang Kyu Lee, Soyeong Jang, Mi Yoo, Dae-Bo Lee, Jeong-Won Hong, Il Suk Noh, and Myung Ho Lim.
    • Department of Psychiatry, National Forensic Hospital, Gongju, Korea.
    • J. Korean Med. Sci. 2018 Sep 10; 33 (37): e231.

    BackgroundThis study examined the clinical effects of leuprolide acetate in sexual offenders with paraphilic disorders evaluated by means of objective psychiatric assessment.MethodsThe subjects of this study were seven sexual offenders who were being treated by means of an injection for sexual impulse control by a court order. They had been diagnosed with paraphilia by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and had been put on probation by the Ministry of Justice between January 2016 and December 2016.ResultsAfter twelve months, we observed significant improvement in symptoms, as decrease of abnormal sexual interest and activity, sexual fantasy, Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Impulsivity (GCI-I). There were a mild feminization of the body shape, feelings of fatigue, and mild hot flushes. No other adverse effect was reported.ConclusionThese results suggested that the clinical effects of leuprolide acetate in sexual offenders might be an effective treatment and safety strategy.

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