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Pediatric blood & cancer · Apr 2014
Case ReportsSustained remission of severe Multicentric Castleman disease following multiagent chemotherapy and tocilizumab maintenance.
- Lucie M Turcotte, Colleen K Correll, Robyn C Reed, and Christopher L Moertel.
- Division of Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, Minnesota.
- Pediatr Blood Cancer. 2014 Apr 1; 61 (4): 737-9.
AbstractCastleman disease is a rare lymphoproliferative disorder, which presents in a unicentric or multicentric fashion. Multicentric Castleman disease (MCD) is associated with significant systemic symptoms, in part related to the underlying role of interleukin-6 in disease pathogenesis. Treatment for MCD has not been well established and prognosis has historically been poor. We present a case of severe MCD in a pediatric patient who has shown sustained remission following multi-agent chemotherapy and targeted maintenance therapy with the interleukin-6 receptor inhibitor, tocilizumab. This represents the first case report of sustained remission of MCD in a pediatric patient following discontinuation of tocilizumab therapy.© 2013 Wiley Periodicals, Inc.
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