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- C Fisser, O W Hamer, R Eiber, M Pfeifer, and C Lerzer.
- Klinik und Poliklinik für Innere Medizin II, Universitätsklinik Regensburg, Regensburg.
- Pneumologie. 2019 Jan 1; 73 (1): 49-53.
AbstractPulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. PAP results from impaired surfactant clearance. In adults, autoimmune pulmonary alveolar proteinosis is present in 90 - 95 % of the cases. In 5 - 10 %, other etiologies such as toxins and dust exposure, hematological disorders and infections have to be considered. Men between 30 - 60 years are commonly affected. Typical symptoms are cough, dyspnea and alteration in ventilatory function. CT scan of the lung is characterised by a crazy paving pattern. In serological testing, granulocyte macrophage colony-stimulation factor can be identified in most patients with autoimmune pulmonary alveolar proteinosis. Whole-lung lavage remains the therapy of choice. In the current case, treatment with whole-lung lavage resulted in clinical and functional improvement.© Georg Thieme Verlag KG Stuttgart · New York.
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