• Proc. Natl. Acad. Sci. U.S.A. · Apr 2014

    Rescuing US biomedical research from its systemic flaws.

    • Bruce Alberts, Marc W Kirschner, Shirley Tilghman, and Harold Varmus.
    • Department of Biophysics and Biochemistry, University of California, San Francisco, CA 94158.
    • Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 22; 111 (16): 5773-7.

    AbstractThe long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches. Instead, it is time to confront the dangers at hand and rethink some fundamental features of the US biomedical research ecosystem.

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