• Neuroscience bulletin · Apr 2017

    Review

    Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies.

    • Dongyun Li, Hans-Otto Karnath, and Xiu Xu.
    • Division of Child Health Care, Children's Hospital of Fudan University, Shanghai, 201102, China.
    • Neurosci Bull. 2017 Apr 1; 33 (2): 219-237.

    AbstractSearching for effective biomarkers is one of the most challenging tasks in the research field of Autism Spectrum Disorder (ASD). Magnetic resonance imaging (MRI) provides a non-invasive and powerful tool for investigating changes in the structure, function, maturation, connectivity, and metabolism of the brain of children with ASD. Here, we review the more recent MRI studies in young children with ASD, aiming to provide candidate biomarkers for the diagnosis of childhood ASD. The review covers structural imaging methods, diffusion tensor imaging, resting-state functional MRI, and magnetic resonance spectroscopy. Future advances in neuroimaging techniques, as well as cross-disciplinary studies and large-scale collaborations will be needed for an integrated approach linking neuroimaging, genetics, and phenotypic data to allow the discovery of new, effective biomarkers.

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