• Eur. J. Cancer · Mar 2007

    Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth.

    • Roberto Bianchi, Alessandra Gilardini, Virginia Rodriguez-Menendez, Norberto Oggioni, Annalisa Canta, Tina Colombo, Giulia De Michele, Sara Martone, Alessandra Sfacteria, Giuseppe Piedemonte, Giovanni Grasso, Patrizia Beccaglia, Pietro Ghezzi, Maurizio D'Incalci, Giuseppe Lauria, and Guido Cavaletti.
    • Mario Negri Institute of Pharmacological Research, Milan, Italy.
    • Eur. J. Cancer. 2007 Mar 1; 43 (4): 710-7.

    AbstractThis study examined the dose-dependent efficacy of erythropoietin (EPO) for preventing and/or treating cisplatin (CDDP) induced peripheral neurotoxicity (CINP), and its influence on tumour treatment and growth. Rats received eight intraperitoneal (ip) injections of 2 mg/kg CDDP twice weekly. EPO co-administered (50 or 10 microg/kg ip, three times/week) had a dose-dependent effect, partially preventing CINP, but 0.5 microg/kg ip was not effective. The neuroprotective effect lasted at least 5 weeks after the last dose of EPO and CDDP. In addition, EPO (50 microg/kg ip three times/week) after the last injection of CDDP still induced a significant recovery of CINP. In a separate experiment in rats bearing mammary carcinoma EPO treatment (50 microg/kg ip) given concurrently with CDDP (1.0 and 1.5 mg/kg twice a week for four weeks) was neuroprotective without influencing the effectiveness of the treatment or tumour growth. EPO thus appears to be an effective neuroprotectant that does not interfere with tumour treatment.

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