• British journal of cancer · Sep 2003

    Clinical Trial

    Phase I/II study of docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small-cell lung cancer.

    • K Kiura, H Ueoka, Y Segawa, M Tabata, H Kamei, N Takigawa, S Hiraki, Y Watanabe, A Bessho, K Eguchi, N Okimoto, S Harita, M Takemoto, Y Hiraki, M Harada, M Tanimoto, and Okayama Lung Cancer Study Group.
    • Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan. kkiura@md.okayama-u.ac.jp
    • Br. J. Cancer. 2003 Sep 1; 89 (5): 795-802.

    AbstractRecent studies have suggested the superiority of concomitant over sequential administration of chemotherapy and radiotherapy. Docetaxel and cisplatin have demonstrated efficacy in advanced non-small-cell lung cancer (NSCLC). This study evaluated the safety, toxicity, and antitumour activity of docetaxel/cisplatin with concurrent thoracic radiotherapy for patients with locally advanced NSCLC. Patients with locally advanced NSCLC (stage IIIA or IIIB), good performance status, age or=3 toxicities of 71, 60, 24, and 19%, respectively. Toxicity was significant, but manageable according to the dose and schedule modifications. Dose intensities of docetaxel and cisplatin were 86 and 87%, respectively. Radiotherapy was completed without a delay in 67% of 42 patients. The overall response rate was 79% (95% confidence interval (CI), 66-91%). The median survival time was 23.4+ months with an overall survival rate of 76% at 1 year and 54% at 2 years. In conclusion, chemotherapy with cisplatin plus docetaxel given on days 1, 8, 29, and 36 and concurrent thoracic radiotherapy is efficacious and tolerated in patients with locally advanced NSCLC and should be evaluated in a phase III study.

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