• Nutrition · Nov 2021

    Review

    Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance.

    • Edwin E Martínez Leo, Abigail Meza Peñafiel, Víctor M Hernández Escalante, and Zulema M Cabrera Araujo.
    • Research Department, University Latino, Merida, Mexico; School of Medicine, Autonomous University of Yucatan, Merida, Mexico. Electronic address: edwin.martinez@docente.universidadlatino.edu.mx.
    • Nutrition. 2021 Nov 1; 91-92: 111419.

    AbstractIn recent years, consumption of ultra-processed food around the world has been increasing. The nutritional profile of an ultra-processed diet is associated with the development of cellular alterations that lead to oxidative stress. The chronic prooxidative state leads to an environment that influences the proliferation, apoptosis, and signaling pathways of immune cells. Likewise, the decrease in the transcription factor NRF2, owing to exacerbated production of reactive oxygen species, leads to changes in immune function and response to infections. This review aims to analyze the connection between an ultra-processed diet, systemic oxidative stress, and immune tolerance, as a contribution to the scientific evidence on the impact of oxidative stress on health and the possible risk of infections-an important consideration in the association of eating pattern and the immune response.Copyright © 2021 Elsevier Inc. All rights reserved.

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