• Asian Pac. J. Cancer Prev. · Jan 2014

    Outcomes of triple-negative versus non-triple-negative breast cancers managed with breast-conserving therapy.

    • Abu Bakar Hafeez Bhatti, Amina Iqbal Khan, Neelam Siddiqui, Nargis Muzaffar, Aamir Ali Syed, Mazhar Ali Shah, and Arif Jamshed.
    • Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan E-mail : Abubakar.hafeez@yahoo.com.
    • Asian Pac. J. Cancer Prev. 2014 Jan 1; 15 (6): 2577-81.

    BackgroundTriple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer.Materials And MethodsMedical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected five year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome.ResultsA total of 194 patients with TNBC and 443 with non-TNBC were compared. Significant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not significantly different. No significant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events.ConclusionsBreast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.

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